Testing standards
Testing standards
Testing standards
Setting the standard for supplement quality
Setting the standard for supplement quality
Setting the standard for supplement quality
An unrevolutionary, yet impactful, three-phase approach makes up our standard.
THE GOOD PILL CO™ certification program is built on three core pillars, ensuring both consumer confidence and a robust standard for Food Supplement companies to adhere to.
Ingredient value accuracy: are the listed ingredients present in the product, and if so, are they present in the stated quantities within a stringent margin of error.
Disintegration/dissolution: do the supplements disintegrate? Disintegration is a prerequisite for efficient nutrient availability and subsequent bodily uptake.
Impurities and contaminants: is the product free from harmful contaminants and impurities linked to the raw materials used in its production?
The GOOD PILL CO™´s analytical work we produce is something you can count on. We employ methods from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house developed methods and we provide you with reliable and reproducible results. THE GOOD PILL CO™ analytical laboratory is certified under GMP and GLP as well as accredited under ISO 17025 for a variety of methods and it employees state of the art instrumentation as well as the latest compendial methods.
THE GOOD PILL CO™ certification program is built on three core pillars, ensuring both consumer confidence and a robust standard for Food Supplement companies to adhere to.
Ingredient value accuracy: are the listed ingredients present in the product, and if so, are they present in the stated quantities within a stringent margin of error.
Disintegration/dissolution: do the supplements disintegrate? Disintegration is a prerequisite for efficient nutrient availability and subsequent bodily uptake.
Impurities and contaminants: is the product free from harmful contaminants and impurities linked to the raw materials used in its production?
The GOOD PILL CO™´s analytical work we produce is something you can count on. We employ methods from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house developed methods and we provide you with reliable and reproducible results. THE GOOD PILL CO™ analytical laboratory is certified under GMP and GLP as well as accredited under ISO 17025 for a variety of methods and it employees state of the art instrumentation as well as the latest compendial methods.
An unrevolutionary, yet impactful, three-phase approach makes up our standard.
THE GOOD PILL CO™ certification program is built on three core pillars, ensuring both consumer confidence and a robust standard for Food Supplement companies to adhere to.
Ingredient value accuracy: are the listed ingredients present in the product, and if so, are they present in the stated quantities within a stringent margin of error.
Disintegration/dissolution: do the supplements disintegrate? Disintegration is a prerequisite for efficient nutrient availability and subsequent bodily uptake.
Impurities and contaminants: is the product free from harmful contaminants and impurities linked to the raw materials used in its production?
The GOOD PILL CO™´s analytical work we produce is something you can count on. We employ methods from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house developed methods and we provide you with reliable and reproducible results. THE GOOD PILL CO™ analytical laboratory is certified under GMP and GLP as well as accredited under ISO 17025 for a variety of methods and it employees state of the art instrumentation as well as the latest compendial methods.
PHASE 1
Ingredient Value Accuracy
In this first phase we identify and measure the labelled bio-active compounds of your supplements. We focus on Vitamins, Essential Minerals, Fish Oils (Omega 3 and Omega 6), Proteins, Probiotics as well as Amino Acids. We also verify the nutritional values of the product including Calories, Carbohydrates, Salt and Fats where relevant.
PHASE 1
Ingredient Value Accuracy
In this first phase we identify and measure the labelled bio-active compounds of your supplements. We focus on Vitamins, Essential Minerals, Fish Oils (Omega 3 and Omega 6), Proteins, Probiotics as well as Amino Acids. We also verify the nutritional values of the product including Calories, Carbohydrates, Salt and Fats where relevant.
PHASE 1
Ingredient Value Accuracy
In this first phase we identify and measure the labelled bio-active compounds of your supplements. We focus on Vitamins, Essential Minerals, Fish Oils (Omega 3 and Omega 6), Proteins, Probiotics as well as Amino Acids. We also verify the nutritional values of the product including Calories, Carbohydrates, Salt and Fats where relevant.
To do this we employ analytical methodologies from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house methods and use state of the art instrumentation, including but not limited to:
To do this we employ analytical methodologies from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house methods and use state of the art instrumentation, including but not limited to:
To do this we employ analytical methodologies from US Pharmacopeia (USP), European Pharmacopeia (EP) as well as in-house methods and use state of the art instrumentation, including but not limited to:
HPLC-UV
High Pressure Liquid Chromatography with Ultraviolet detector
HPLC-UV
High Pressure Liquid Chromatography with Ultraviolet detector
HPLC-UV
High Pressure Liquid Chromatography with Ultraviolet detector
HPLC-UV
Ultra Performance Liquid Chromatography couple with Double Quadrupole Mass Spectrometer
HPLC-UV
Ultra Performance Liquid Chromatography couple with Double Quadrupole Mass Spectrometer
HPLC-UV
Ultra Performance Liquid Chromatography couple with Double Quadrupole Mass Spectrometer
HPLC-MS
High Pressure Liquid Chromatography coupled with Mass Spectrometer
HPLC-MS
High Pressure Liquid Chromatography coupled with Mass Spectrometer
HPLC-MS
High Pressure Liquid Chromatography coupled with Mass Spectrometer
FTIR
Fourier Transform Infrared Spectroscopy
FTIR
Fourier Transform Infrared Spectroscopy
FTIR
Fourier Transform Infrared Spectroscopy
ICP-MS
Ion Coupled Plasma coupled with Mass Spectrometer
ICP-MS
Ion Coupled Plasma coupled with Mass Spectrometer
ICP-MS
Ion Coupled Plasma coupled with Mass Spectrometer
GC
Gas Chromatography
GC
Gas Chromatography
GC
Gas Chromatography
GC-MS
Gas Chromatography coupled with Mass Spectrometer
GC-MS
Gas Chromatography coupled with Mass Spectrometer
GC-MS
Gas Chromatography coupled with Mass Spectrometer
PCR
Polymerase Chain Reaction
PCR
Polymerase Chain Reaction
PCR
Polymerase Chain Reaction
NGS
Next Generation Sequencing
NGS
Next Generation Sequencing
NGS
Next Generation Sequencing
ELISA
Enzyme-linked Immunosorbent Assay
ELISA
Enzyme-linked Immunosorbent Assay
ELISA
Enzyme-linked Immunosorbent Assay
Laboratory Benchwork of Compendial Methods
Laboratory Benchwork of Compendial Methods
Laboratory Benchwork of Compendial Methods
PHASE 2
Disintegration/Dissolution
In this second step we make sure that the supplement disintegrates in our bodies and therefore renders its bio-active compounds available for bodily uptake.
When you consume a supplement, it undergoes digestion in the gastrointestinal tract. The active ingredients are then absorbed into the bloodstream through the intestinal walls. From there, they enter systemic circulation, allowing them to be transported to various parts of the body where they can exert their effects.
The bioavailability, or the extent and rate at which the active ingredients are absorbed and become available at the site of action, can vary widely among different supplements. Factors influencing bioavailability include the supplement's formulation (such as whether it is a liquid, capsule, tablet, or powder), the presence of other components or nutrients, and individual factors like metabolic rate and gastrointestinal health.
Disintegration is thus a prerequisite for efficient nutrient availability and subsequent bodily uptake. Without it even high-quality products may fail to be absorbed, rendering the supplement inefficient.
Compliance with the limits on Disintegration stated in the individual monographs for supplements is required except for Delayed release (enteric coated tablets) and Timed or slow release claiming supplements where USP methodology will be followed using gastric fluid simulant or 0.1M HCl for a period no greater than 8 hours. In these slow or delayed release cases the supplements should not disintegrate within the first hour. Chewables, powders, and liquids are exempt from disintegration testing requirements.
Standard disintegration will follow USP and EP monographs where applicable. In case of no such monograph being present disintegration will be carried out over 60 min in deionized water.
In this step the instrumentation used is a Disintegration Tester.
PHASE 2
Disintegration/Dissolution
In this second step we make sure that the supplement disintegrates in our bodies and therefore renders its bio-active compounds available for bodily uptake.
When you consume a supplement, it undergoes digestion in the gastrointestinal tract. The active ingredients are then absorbed into the bloodstream through the intestinal walls. From there, they enter systemic circulation, allowing them to be transported to various parts of the body where they can exert their effects.
The bioavailability, or the extent and rate at which the active ingredients are absorbed and become available at the site of action, can vary widely among different supplements. Factors influencing bioavailability include the supplement's formulation (such as whether it is a liquid, capsule, tablet, or powder), the presence of other components or nutrients, and individual factors like metabolic rate and gastrointestinal health.
Disintegration is thus a prerequisite for efficient nutrient availability and subsequent bodily uptake. Without it even high-quality products may fail to be absorbed, rendering the supplement inefficient.
Compliance with the limits on Disintegration stated in the individual monographs for supplements is required except for Delayed release (enteric coated tablets) and Timed or slow release claiming supplements where USP methodology will be followed using gastric fluid simulant or 0.1M HCl for a period no greater than 8 hours. In these slow or delayed release cases the supplements should not disintegrate within the first hour. Chewables, powders, and liquids are exempt from disintegration testing requirements.
Standard disintegration will follow USP and EP monographs where applicable. In case of no such monograph being present disintegration will be carried out over 60 min in deionized water.
In this step the instrumentation used is a Disintegration Tester.
PHASE 2
Disintegration/Dissolution
In this second step we make sure that the supplement disintegrates in our bodies and therefore renders its bio-active compounds available for bodily uptake.
When you consume a supplement, it undergoes digestion in the gastrointestinal tract. The active ingredients are then absorbed into the bloodstream through the intestinal walls. From there, they enter systemic circulation, allowing them to be transported to various parts of the body where they can exert their effects.
The bioavailability, or the extent and rate at which the active ingredients are absorbed and become available at the site of action, can vary widely among different supplements. Factors influencing bioavailability include the supplement's formulation (such as whether it is a liquid, capsule, tablet, or powder), the presence of other components or nutrients, and individual factors like metabolic rate and gastrointestinal health.
Disintegration is thus a prerequisite for efficient nutrient availability and subsequent bodily uptake. Without it even high-quality products may fail to be absorbed, rendering the supplement inefficient.
Compliance with the limits on Disintegration stated in the individual monographs for supplements is required except for Delayed release (enteric coated tablets) and Timed or slow release claiming supplements where USP methodology will be followed using gastric fluid simulant or 0.1M HCl for a period no greater than 8 hours. In these slow or delayed release cases the supplements should not disintegrate within the first hour. Chewables, powders, and liquids are exempt from disintegration testing requirements.
Standard disintegration will follow USP and EP monographs where applicable. In case of no such monograph being present disintegration will be carried out over 60 min in deionized water.
In this step the instrumentation used is a Disintegration Tester.
PHASE 3
Impurities and Contaminants
Finally our third pillar of quality consists in verifying that the Food Supplement does not contain contaminants related to the raw materials used in its production. Here we assess the microbial sterility of the product and we test for the presence of heavy metals as well as other ingredient-specific contaminants and impurities.
We test for Heavy metals. (As, Pb, Hg, Cd) using ICP-MS instrumentation
We test the microbial purity of the formulation and particularly for Total Aerobic Microbial Count (TAMC), Total Yeasts and Molds Count (TYMC), Staphylococcus Aureus, E. Coli, Salmonella, Pseudomonas Aeruginosa, Bile-tolerant Gram-negative bacteria.
Contaminants can pose serious health risks even at low levels. Comprehensive screening ensures the safety and purity of supplements, protecting end-users from potential toxicities and supporting compliance with stringent regulatory standards.
PHASE 3
Impurities and Contaminants
Finally our third pillar of quality consists in verifying that the Food Supplement does not contain contaminants related to the raw materials used in its production. Here we assess the microbial sterility of the product and we test for the presence of heavy metals as well as other ingredient-specific contaminants and impurities.
We test for Heavy metals. (As, Pb, Hg, Cd) using ICP-MS instrumentation
We test the microbial purity of the formulation and particularly for Total Aerobic Microbial Count (TAMC), Total Yeasts and Molds Count (TYMC), Staphylococcus Aureus, E. Coli, Salmonella, Pseudomonas Aeruginosa, Bile-tolerant Gram-negative bacteria.
Contaminants can pose serious health risks even at low levels. Comprehensive screening ensures the safety and purity of supplements, protecting end-users from potential toxicities and supporting compliance with stringent regulatory standards.
PHASE 3
Impurities and Contaminants
Finally our third pillar of quality consists in verifying that the Food Supplement does not contain contaminants related to the raw materials used in its production. Here we assess the microbial sterility of the product and we test for the presence of heavy metals as well as other ingredient-specific contaminants and impurities.
We test for Heavy metals. (As, Pb, Hg, Cd) using ICP-MS instrumentation
We test the microbial purity of the formulation and particularly for Total Aerobic Microbial Count (TAMC), Total Yeasts and Molds Count (TYMC), Staphylococcus Aureus, E. Coli, Salmonella, Pseudomonas Aeruginosa, Bile-tolerant Gram-negative bacteria.
Contaminants can pose serious health risks even at low levels. Comprehensive screening ensures the safety and purity of supplements, protecting end-users from potential toxicities and supporting compliance with stringent regulatory standards.
Probiotics testing
To certify the presence and population of probiotic ingredients, we employ advanced enumeration techniques to accurately count and verify the presence of beneficial bacteria. This process typically involves culturing probiotic samples on selective growth media to isolate and identify specific strains. Using colony-forming unit (CFU) counts, we determine the number of live bacteria in each sample. Additionally, molecular techniques such as quantitative PCR (qPCR) can be used to detect and quantify bacterial DNA, ensuring strain-specific accuracy. These methods allow us to confirm that probiotic products meet the declared population and are specific to the strains intended, ensuring their effectiveness and safety for consumers.
Probiotics testing
To certify the presence and population of probiotic ingredients, we employ advanced enumeration techniques to accurately count and verify the presence of beneficial bacteria. This process typically involves culturing probiotic samples on selective growth media to isolate and identify specific strains. Using colony-forming unit (CFU) counts, we determine the number of live bacteria in each sample. Additionally, molecular techniques such as quantitative PCR (qPCR) can be used to detect and quantify bacterial DNA, ensuring strain-specific accuracy. These methods allow us to confirm that probiotic products meet the declared population and are specific to the strains intended, ensuring their effectiveness and safety for consumers.
Probiotics testing
To certify the presence and population of probiotic ingredients, we employ advanced enumeration techniques to accurately count and verify the presence of beneficial bacteria. This process typically involves culturing probiotic samples on selective growth media to isolate and identify specific strains. Using colony-forming unit (CFU) counts, we determine the number of live bacteria in each sample. Additionally, molecular techniques such as quantitative PCR (qPCR) can be used to detect and quantify bacterial DNA, ensuring strain-specific accuracy. These methods allow us to confirm that probiotic products meet the declared population and are specific to the strains intended, ensuring their effectiveness and safety for consumers.